GenoVive Nutrigenomic Test


caravaggio_boy_with_fruitWhat if you could ask your body a direct question. What if you could say, “Hey body. Thanks for everything you do for me. I’d like to nourish you. What would your ideal food be?”

Your body might say, “Hey, thanks! So nice of you to ask!  When it comes to food, I think more along the lines of overall fuel. So, how about I tell you what mix of carbohydrates, fats and proteins I’d work best with, and then you can work with your dietitian to figure out what specific meals would look like?”

Then you would give your body a high-5. Which I guess would be a clap… which would be appropriate, because providing your body with what it needs to reach its highest potential is something to applaud, and the GenoVive Nutrigenomic Test allows you to do just that!

Knowing what mix of proteins, fats and carbs would make your 70 trillion cells work most efficiently and optimally would remove so much mystery! If only we could catch a glimpse of the instructions your cells reference when building themselves…

…Well, you guessed it: We can! It’s amazing that we live in a time when we can indeed consult your DNA for clues to your body’s ideal nutrition! The GenoVive Genetic Test is aimed at supporting weight loss, but can aid any health goal (like optimizing fitness programs, recovering from a chronic illness, improving energy and supporting a health condition).

The Scientific Advisory Board at Genovive Labs has compiled nutrigenetic information on 22 genes to create a report of which nutrition and fitness strategies are right for you (you personally!) More than 500 sources were referenced (and counting as the science is fresh and bourgeoning)! Each individual’s genetic variations determine the way in which their body regulates fat and carbohydrate intake, metabolizes calories and responds to exercise. That’s why certain diets work for some, but not everyone.

The “Calories In/Calories Out” strategy of weight loss is old news. Sure, the energy stored in food plays a part, but more important is a meal or snack’s mixture of carbs, protein and fat. Eating the same number of calories in pasta or steak will have completely different biochemical consequences. That is what makes the difference in producing efficient weight loss results, and this test eliminates the guessing game!

What is included in this test?

Nutrition-Related Results

Which of four distinct meal types your body prefers*:

  1. Overall Balance: fats, proteins and carbs are balanced, with an emphasis on portion and calorie control
  2. Carbohydrate-Optimized: fats and proteins are emphasized, while carbohydrates are reduced
  3. Fat-Optimized: proteins and carbohydrates are emphasized, while fat is reduced
  4. Fat & Carbohydrate-Optimized: proteins are emphasized, while fats and carbohydrates are reduced.

*The recommended meal types are all balanced. In other words, none completely eliminate any macronutrients like Atkins does. As we work together, we may find it’s ideal to be slightly strict with macronutrient balance at first. In the future, when your desired amount of weight is released, your functional needs will change.

 

Fitness-Related Results

What type of exercise is optimal for your body*:

  • Power vs. endurance
  • High-intensity vs. sustained aerobic activity

The constitution of your muscle fibers:

  • Slow-twitch
  • Fast-twitch
  • Balanced

*I highly recommend that you consult with a professional trainer before instituting any changes suggested in the GenoVive report. Depending on your current activity and physical fitness level, you may need to plan a strategy that comfortably and safely transitions to the recommendations. I highly recommend fellow members of iHEC: Christine Flory of Flory Fitness, Joe Gazmen of CrossFit Aliquid and Joby Shreckhise of CrossFit 3xf.

 

Behavior-Related Results

The following genetic predispositions are analyzed and explained:

  • Hunger and satiety. Your genetic programming of the hunger-stimulating hormone called ghrelin, as compared to leptin, the satiety-inducing hormone.
  • Eating for pleasure in the absence of hunger. Genetics can affect dopamine receptors in the brain and cause them to overproduce dopamine and strain your willpower.
  • Appetite and energy output levels. The body has a natural set point for how much fat tissue it wants to accumulate. This is related to the hormone leptin.
  • Taste and food preference. Some foods taste different to different people. If you are a supertaster of bitter foods, you might avoid cruciferous veggies, like broccoli and cabbage, and prefer sweet foods. Some people actually have more tastebuds.
  • Sugar cravings. Genetics plays a role in blood sugar levels and brain chemistry, two of the main factors that cause us to crave sugar.
  • Mood and food selection. Flaws in folate metabolism and the MTHFR gene have been connected to mood regulation. When mood experiences a downswing, it may be more likely for the body to seek solace in foods.

*No matter the results of these tests, there are always ways to overcome these genetic influences. Genes are not the entire story. When you eat meals with the correct balance of carbs, fats and proteins, your body will be less apt to sound the alarm bells that demand crunch, salty, sweet or chocolaty snacks.

 

Specific Genes Included in Analysis

  1. FTO gene affects the hypothalamus, a region in the brain that regulates appetite, energy regulation and satiety.
  2. APOA2 plays a role in the composition of fat molecules found in blood and tissues, as well as tendency towards triglyceride formation.
  3. TCF7L2 is a key regulator of glucose metabolism in the liver and affects the metabolism of dietary fat.
  4. IRS1 is involved in the insulin signaling pathway and in generating energy from carbohydrates.
  5. GIPR is involved in the release of insulin after the ingestion of glucose and fat.
  6. LIPC is related to blood lipid levels.
  7. PPARG2 is involved in fat and carbohydrate metabolism, as well as in fat cell formation.
  8. IL6 plays a role in glucose and lipid metabolism. Certain versions of this gene tend to have higher insulin levels and higher levels of body fat.
  9. TNF is a key player in regulating the body’s inflammatory response. Chronic, systemic inflammation has been linked to excess weight gain.
  10. LIPC (-514) is related to blood lipid levels.
  11. LIPC (-250) is related to blood lipid levels.
  12. FABP2 is involved in the speed of absorption of dietary fats from the digestive tract.
  13. ADRB2 (Gln27Glu) is important in the mobilization of stored fat, especially with a high-carbohydrate diet.
  14. ADRB2 (Arg16Gly) is important in the mobilization of stored fat, especially with a high-carbohydrate diet.
  15. ADRB3 is important in energy metabolism and in reducing abdominal and subcutaneous fat.
  16. ACE is associated with abdominal adiposity (belly fat) and indicates a benefit from high-intensity workouts.
  17. eNOS is the key promotor for the production of nitric oxide (NO). NO plays a role in regulating vascular tone and vasodilation, which determines the amount of oxygen that’s delivered to muscles.
  18. ACTN3 helps discern between fast and slow-twitch muscles.
  19. DRD2 is involved with the production of dopamine, which is responsible for the feeling of pleasure.
  20. GLUT2 has been linked to sugar cravings.
  21. IRS1 is involved in insulin sensitivity.
  22. LEPR is involved in producing the leptin receptor. Leptin is a hormone that helps regulate the body’s levels of fat, as well as satiety.
  23. MTHFR is chiefly involved with the activation of folate. Read more about MTHFR.
  24. TAS2R38 is associated with sensitivity to certain bitter compounds in foods, namely those in cruciferous vegetables.

 

Frequently Asked Questions

What exactly is Nutrigenomics? Find more info here.

Is the GenoVive test a blood test? Do I need to go to a lab?

  • Nope! It’s a painless cheek swab. You’ll take a cotton swab, rub it on the inside of your cheek, pop it into an envelope, mail it and go on about your day.

How do I get this exciting test?

  • Join a Group class or Individual Consult. We will complete the test at class or in my office and then meet one week later to go over the results.

Is genetic testing safe, or am I risking my private information?

What’s up with the meal plans GenoVive sells?

  • This is a great service that I will explain to anyone who is interested. While I think it’s ideal for everyone to eat locally-grown foods as often as possible, some people prefer and benefit from a Meal Delivery service. GenoVive offers a great one.

How can I find out about more of my genes?

  • For about $250, you can learn about thousands of your genes. Interpreting them is another story, but I can help! Go to 23andme.com to order your test, then give me a call when the results come back… then again, maybe we should chat before then since results can take up to 6 weeks.