Organic Acids Test (OAT)


The Organic Acids Test (OAT) provides a snapshot of what’s going on in your body, which can be used to sleuth out the underlying cause of chronic and/or baffling symptoms and conditions. It measures 74 metabolites that your body has discarded via urine. These compounds are byproducts of cellular activity, digestion of foods and the activity of microbial flora. If they are present at high enough levels, they can indicate dysfunction.

Benefits of an OAT

  • Offers a more complete and accurate evaluation of bacterial and yeast abnormalities than any other test. By testing for metabolic byproducts and not the microorganisms themselves, there is no risk of a false negative.
  • Uncovers select nutrient deficiencies (riboflavin, B5, B6, B12, biotin, vitamin C, CoQ10 and N- acetyl cysteine (a precursor for glutathione, the body’s master antioxidant)).
  • Requires a non-invasive, painless urine sample, which can be done at home with no needles. Overnight FedEx shipping is included in the cost.
  • Many insurance companies cover the test, either in part or in full. (Tricare and Medicare almost always cover the test 100%!) Call your insurance company, then run the info by me. If your company does not participate, I’ll explain Great Plain’s GPL4U program, which makes the test very affordable.
  • More information here: http://www.greatplainslaboratory.com/home/eng/full_oat.asp

After your results arrive in my inbox, we’ll meet to discuss the findings and
various actions that you might choose to take. Potential treatments include antimicrobial products, probiotics, vitamins, antioxidants and dietary modification.

Conditions that may benefit from an OAT include:

  • Fibromyalgia
  • Leaky gut
  • Flares of Autism Spectrum Disorders
  • Chronic Fatigue
  • Depression
  • Anxiety
  • Insomnia
  • Endometriosis
  • Diarrhea & Constipation
  • Colitis & Crohn’s disease
  • Recurrent infections
  • Learning disabilities
  • Alzheimer’s Disease
  • ADD/ADHD & behavioral problems
  • Difficulty releasing weight
  • Obsessive Compulsive disorder
  • Tourette Syndrome
  • Tic disorders

A Selection of the 74 Metabolites Analyzed by an OAT

  • Oxalic acid: a natural molecule that binds to calcium and crystalizes when in contact with damaged tissue. It is sharp like a tiny shard of glass and can cause pain, such as in fibromyalgia. It comes from three sources: foods, microbes like Candida and the body’s own metabolism.
  • Arabinose: produced by Candida, which may be the cause of high oxalates. Since arabinose is also a major sugar in apples, grapes, and pears, these fruits and their products must be avoided 24 hours prior to urine collection to avoid interference.
  • HPHPA: indicates an overgrowth of certain Clostridia bacteria in the GI tract. This metabolite is commonly elevated in autism, psychiatric disorders, and gastrointestinal disorders. It inhibits the enzyme dopamine-beta-hydroxylase, leading to neurotransmitter imbalance.
  • 2-hydroxy- phenyl acetic acid: associated with intestinal bacteria overgrowth.
  • DHPPA: associated with increased amounts of beneficial bacteria in the gastrointestinal tract.
  • Malic acid: a marker for Mitochondrial Dysfunction. The mitochondria are the energy factories for each of your 70 trillion cells. If they falter, energy and metabolism will be affected.
  • Quinolinic acid: a marker for inflammation and neurotoxicity. Excitotoxic substances like quinolinic acid may stimulate nerve cells so much that the nerve cells die. Brain toxicity due to quinolinic acid has been implicated in Alzheimer’s disease, autism, Huntington’s disease, stroke, dementia from old age, depression, HIV-associated dementia, and schizophrenia.
  • 4- Hydroxyhippuric acid: may be elevated after exposure to paraben antimicrobials in certain foods and cosmetics. For some people, an elevated value may be from intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates.

Download this information in a PDF file.

Or, take a look at this flier from Great Plains Labs.